Pain, as an immediate or long-term sequela of myelitis, is highly prevalent in both AQP4-IgG-positive and AQP4-IgG-negative NMOSD [8, 9, 17, 104, 162] and includes neuropathic pain [9], painful tonic spasms [22, 104, 129], neuropathic pruritus [35, 54], and spasticity-associated pain [9]; dysesthesia (often girdle-like in the case of thoracic myelitis) and hyperalgesia/allodynia are frequent [162]. Here, AQP4 is linked to myelitis.