NFE2L2 and COVID-19: In addition, a study with differential gene expression analysis using publicly available transcriptome data sets of lung biopsy specimens from adult COVID-19 patients has shown that, while genes linked with inflammatory and antiviral pathways, including RIG-I receptor and Toll-like receptor (TLR) signaling were enriched in these samples, genes associated with the NRF2-dependent antioxidant response were suppressed in the same patients (25).