At baseline, brain age gap was correlated with chemerin (r=0.22, p=0.029), and with obesity-associated measurements obtained by MRI including visceral abdominal tissue (VAT): r=0.23, p=0.02 and superficial subcutaneous fat (SSC): r=−0.25, p=0.014. This evidence concerns the gene RARRES2 and obesity due to melanocortin 4 receptor deficiency.