HLA-C and breast cancer: Taken together, these results suggested that Scissor+ tumor cells (MHC‐deficient) not only may evade immune surveillance via downregulating interferon signaling and the JAK‐STATs pathway to reduce MHC (mainly includes MHC I and II) genes expression (Figure 3B), but also upregulate multiple risk factors and downregulate protective factors to cause the worse prognosis of breast cancer patients (Figure 3B).