COL1A1 and cancer: Functional analysis showed that these upregulated DEGs in COL1A1+ CAFs were significantly enriched in “Protein processing in endoplasmic reticulum,” “Tight junction,” “ECM‐receptor interaction,” “Proteoglycans in cancer,” “Focal adhesion,” and “Regulation of actin cytoskeleton,” etc. (Figure 5F), but these downregulated DEGs were only enriched in “ribosomes” (Figure 5F).