Remarkably, our results demonstrated detailed ligands and receptors (Figure S4B), and found that CD99‐CD99 could mediate the interaction between Scissor+ tumor cells, myeloid cells, and T cells (Figure 6D), as well as MHC I‐mediated antigen presentation interaction was significantly decreased in tumor cells and Scissor+ tumor cells, especially MHC II‐mediated antigen presentation was absent in Scissor+ tumor cells (Figure 6D). Here, CD99 is linked to neoplasm.