Taken together, these results suggested that Scissor+ tumor cells (MHC‐deficient) not only may evade immune surveillance via downregulating interferon signaling and the JAK‐STATs pathway to reduce MHC (mainly includes MHC I and II) genes expression (Figure 3B), but also upregulate multiple risk factors and downregulate protective factors to cause the worse prognosis of breast cancer patients (Figure 3B). The gene discussed is HLA-C; the disease is neoplasm.