We found that the interactions between COL1A1+ CAFs and tumor cells and Scissor+ tumor cells were mainly mediated by collagen, including COL1A1‐SDC1, COL1A2‐SDC1, COL4A1‐SDC1, COL4A2‐SDC1, COL6A2‐SDC1, and COL6A2‐SDC1, especially Scissor+ tumor cells had stronger interaction with COL1A1 + CAFs (Figure 6H). This evidence concerns the gene COL4A2 and neoplasm.