To reveal how Scissor+ tumor cells cause the poor overall survival in breast cancer patients, we further identified 200 upregulated and 317 downregulated DEGs in Scissor+ tumor cells and other tumor cells (Figure 2D and Table S2), finding that these top downregulated genes in Scissor+ tumor cells were IFI6, BTG2, CD74, SLC39A6, and SAA1, etc., while the top upregulated genes were KRT81, SCGB1B2P, GRB7, MIEN1, and ERBB2 (also called HER2), etc. (Figure 2D). This evidence concerns the gene GRB7 and breast cancer.