To explore whether N/OFQ‐NOP regulates the B‐cell function, migration was measured using the fluorescent marker Bodipy and the chemoattractants CXCL13 and IL‐4 under control conditions and with LPS (100 ng·ml−1)/PepG (20 μg·ml−1) as a mimic of in vitro sepsis. The gene discussed is IL4; the disease is Sepsis.