Several linkage studies involving both Northern and Southern Italian families, with individuals who were phenotypically identical to FAME1, also mapped to the chromosome 2 ADCME interval, strongly suggesting ADCME and FAME1 were variants of the same epilepsy syndrome but mapping to different genes (OMIM, FAME2: 607876).10, 11, 12. The gene discussed is SAMD12; the disease is epilepsy syndrome.