Isolated variants, all of which fell outside known FAME linkage intervals, were also identified: NM_015902.6:c.5720G > A:p.(Arg1907His) in UBR5 in a Chinese family,24 NM_003560.4:c.475G > A, p.Ala159Thr in PLA2G6 in a Chinese family (who now have a confirmed SAMD12 repeat expansion),25, 26 NM_138326.3:c.77G > A:p(Trp26*) in ACMSD in a Spanish family,27 and NM_003946.7:c.61G > C:p.(Glu21Gln) in NOL3 in a Canadian family with familial cortical myoclonus without epilepsy.28 This evidence concerns the gene SAMD12 and epilepsy.