Here, we highlight the close connection between the findings described in a recent series of studies which, together, strongly imply a continuous association between survival outcome, the transcriptional profile of a Group3/Group4 (i.e. non‐WNT/non‐SHH) medulloblastoma and the specific point during early foetal cerebellar development at which initial pathogenic disruption took place. This evidence concerns the gene SHH and medulloblastoma.