At present, several mechanisms are applied to explain the decreased osteogenic differentiation capacities of PDLSCs caused by periodontitis: the activation of classical Wnt/β‐catenin signaling pathway to inhibit the osteogenic differentiation capacities of PDLSCs (Liang et al., 2016), the activation of nonclassical (Wnt/Ca2+) signaling pathway to promote the osteogenic differentiation capacities of PDLSCs (Han et al., 2016), and the activation of a PERK signaling pathway to promote the osteogenic differentiation capacities of PDLSCs (Tan et al., 2016). This evidence concerns the gene EIF2AK3 and periodontitis.