The above research suggests that Gcn5‐mediated histone modification and Wnt/β‐catenin and NF‐kB pathways play an important role in regulating cartilage development, bone marrow stem cell osteogenic differentiation and angiogenesis, and can provide new options for the treatment of bone differentiation and osteoporosis (Kahata et al., 2004) (Figure 2). This evidence concerns the gene KAT2A and osteoporosis.