Copeptin levels were found slightly higher in patients with both type 1 and T2DM than in healthy individuals (Roussel et al., 2017; Jensen et al., 2019) and, in this regard, an acceleration in the turnover of body fluids due to glycosuria, as well as a reset of the osmostat have been hypothesized (Marton et al., 2021). This evidence concerns the gene AVP and type 2 diabetes mellitus.