In addition, IL-1β, linked to sarcoidosis in a number of recent publications (Talreja et al., 2019; Huppertz et al., 2020; Wahlund et al., 2020), appears to be a reliable predictor of granuloma response in this model and, therefore, could act as a biomarker for response in future studies. This evidence concerns the gene IL1B and Granuloma.