Studies have shown that the uptake of modified LDL is mediated by scavenger receptors on the cell surface, such as CD36 and SR-A1, but CD36-and SR-A1-mediated uptake is not regulated by the negative feedback associated with intracellular cholesterol (Syvaranta et al., 2014), Song et al. showed that zafirlukast can prevent foam cells formation by reducing CD36 protein expression and inhibiting the influx of cholesterol in asthma treatment (Song et al., 2020). The gene discussed is SRA1; the disease is asthma.