Here, utilizing DS mice (Scn1aA1783V/WT) we show that acute administration of Dravet-recommended drugs, VA, CLB, a combination of CLB + STP, or STP alone, was associated with a reduction in the frequency of interictal spikes in most of the tested mice, along with a significant increase in relative beta band contribution to the total power. Here, CLYBL is linked to Dravet syndrome.