STING1 and melanoma: As cyclic dinucleotides (CDNs) like c-di-GMP (CDG) are agonists for stimulator of interferon genes (STING), STING-activating DNA nanovaccines (STING-NVs) with i-motif DNA on the surface showed potential to improve immunosuppression in vitro and in vivo in a murine melanoma model.