By suppressing mRNA expression levels of Bcl-2, cyclin D1, Bcl-xL, MMP-2, and vascular endothelial growth factor (VEGF) in MDA-MB-231 and MCF-7 breast cancer cells, DATS intervention significantly reduced leptin-induced cell proliferation, clonogenic cell viability, invasion and migration potential. The gene discussed is MMP2; the disease is breast cancer.