RYR1 and Malignant hyperthermia: Of these, CYP3A5*6 (p.Lys208 = ) related with an LoF allele by splicing defect is 3.3 times more frequent in Colombian population, Our analysis demonstrated that 43.1% (60/123) of pathogenic rare missense, LoF and splice site molecular variants (Supplementary Table 2) found in this study are located in RYR1 and CACNAS1 genes, which are related to the malignant hyperthermia phenotype.