However, we observed that UPR is not required for ferroptosis in metastatic melanoma cells, despite a clear and early upregulation of CHAC1, that could be be abrogated by inhibiting NRF2, suggesting that CHAC1 is under control of both UPR and NRF2 (Gagliardi et al., 2019; Gagliardi et al., 2020). This evidence concerns the gene NFE2L2 and melanoma.