In rubella, we found five significant genes, namely, JAGN1 (padjusted = 0.036), RRP12 (padjusted = 0.017), RP11-452K12.7 (padjusted = 0.006), CASP7 (padjusted = 0.048), and AP3S2 (padjusted = 0.020) in the whole blood, while in the lung tissue, we found IL17RC (padjusted = 0.035), FAM86HP (padjusted = 0.034), AMACR (padjusted = 0.012), and RRP12 (padjusted = 0.006) to be significantly associated with rubella. This evidence concerns the gene AP3S2 and rubella.