Colorectal cancer model is the most studied cancer model, and a number of studies have shown that a variety of NLR inflammasomes are closely related to it, among which NLRC3, NLRC4, NOD2, NLRP1, NLRP6, NLRP12 inflammasomes have protective effects on colorectal cancer, while the effects of NLRP3 and NOD1 inflammasomes are still controversial (50). This evidence concerns the gene NOD2 and colorectal cancer.