In the multivariate analysis using multiple Cox proportional hazards models, we observed that the performance status (KPS<70, p= 0.006), BM at the time of initial lung cancer diagnosis (p= 0.024), BM progression after TKI (p=0.000), EGFR mutation (p=0.023), uncontrolled primary tumor (p=0.002), and more than three BM (p=0.005) were the independent prognostic factors for OS (Table 2). This evidence concerns the gene EGFR and lung carcinoma.