Univariate analysis of the clinical and radiographic factors showed that serum tumor marker levels, including NSE, CEA, and CA125, as well as the visual assessment of CT signs such as contour, pleural indentation, spiculation, air bronchogram, and lobulation, were significantly related to PSCLC (P<0.05), as shown in Table 2. This evidence concerns the gene CEACAM5 and neoplasm.