Notably, TRPV4-mediated dilation in mouse pial arteries is impaired in the mouse model of AD (Zhang et al., 2013); likewise, TRPV4 is shown to be fundamental in parenchymal arteriolar dilation and cognitive function in hypertension (Diaz-Otero et al., 2018, 2019). Here, TRPV4 is linked to hypertensive disorder.