TGFB1 and Familial prostate cancer: In addition, hsa_circ_0001085 may indirectly regulate the PI3K-Akt and TGF-β signaling pathways through hsa_miR-196b-5P and the MAPK signaling pathway through hsa_miR-451A, thereby playing a regulatory role in the EMT-induced model of prostate cancer cells [19].