The findings revealed that cervical cancer tissue with a higher EREG level had higher mutative frequencies of HECTD4, NBAS, THSD7A, BRCA2, CENPE, VWF, STK11, NBEAL2, STAB1, DMXL1, GOLGA4, GANAB, and KIAA1549. This evidence concerns the gene HECTD4 and cervical cancer.