Neuropilin-2 regulates lymphatic metastasis and production, Using the CRISPR/Cas9 technique to knock out the Nrp2 gene of colorectal cancer cells with mesenchymal phenotype, the mesenchymal transformation into epithelium was found with de novo dependence on insulin receptor (IR) signaling and autophagy. Here, NRP2 is linked to colorectal cancer.