NSD2 and colonic neoplasm: studied the interaction between HMGA2-WHSC1 in the regulation of cancer cell growth and found that WHSC1 is a transcriptional target of the oncogene HMGA2, which can promote cancer cell proliferation and metastasis.CRISPR knockout of WHSC1 in colon cancer cells inhibits colon cancer cell proliferation, increases drug sensitivity, and decreases metastatic ability (14).