found through in vitro, in vivo, subcutaneous, and intravenous injection experiments that compared with the control group, HCT116 cells with caspase-3 gene knockout showed increased sensitivity to chemotherapy and radiotherapy, and weakened tumor invasiveness and metastasis ability, suggesting that caspase-3 can be used as a therapeutic target for colon cancer (19). Here, CASP3 is linked to colonic neoplasm.