found that tumor cells develop a tolerance to oxaliplatin due to chromatin alterations, fibroblast growth factor receptor 1(FGFR1) and oxytocin receptor (OXTR) are genes associated with increased chromatin accessibility, CRISPR/Cas9 silencing fibroblast growth factor receptor 1 (FGFR1) and oxytocin receptor (OXTR) helps overcome oxaliplatin resistance. The gene discussed is OXTR; the disease is neoplasm.