Therefore, based on the analysis of the characteristics and mechanisms of PAI-1 circadian rhythm generation, the elaboration of the relationship between PAI-1 and diabetic cardiovascular disease, and the assessment of the therapeutic prospects of related drugs for diabetic cardiovascular complications, we summarized the possibility of using the circadian rhythm of PAI-1 to treat the cardiovascular complications of diabetes using “chronotherapy”. Here, SERPINE1 is linked to complication.