Treatment of EMS horses with the PTP1B inhibitor MSI-1436 resulted in a significant regulation of both insulinemia and glycemia (Figures 8C, D), which appeared lower compared to non-treated EMS animals (p<0.001; p<0.01), suggesting an amelioration of the insulin and glycaemic control and a probable attenuation of insulin resistance over a period of 4 weeks post-treatment. This evidence concerns the gene PTPN1 and Insulin resistance.