MTOR and Hyperglycemia: LncRNAs potently affect the pathological alteration in the diabetic kidney by inhibiting the autophagy-related Akt/mTOR pathway, which has been supported by growing evidence that LncRNA silencing sperm-associated antigen 5 antisense RNA1 promotes hyperglycemia-induced injury in podocytes targeting Akt/mTOR signaling (37), and LncRNA nuclear enriched abundant transcript 1 accelerates (58), whereas LncRNA SOX2 overlapping transcript inhibits (15), proliferation and fibrosis in diabetic GMCs via modulating Akt/mTOR signaling-related autophagy.