In addition, Lactobacillus rhamnosus GG (LGG) treatment enhanced the efficacy of immune checkpoint blockade (ICB) therapies through inducing cGAS/STING-dependent IFN-β production in colorectal cancer therapy, which suggesting that cGAS-STING axis play a vital role in anti-tumor immune responses against HCC (96). This evidence concerns the gene STING1 and colorectal cancer.