Glomerulosclerosis was positively correlated with the abundances of 11 urinary complements, including C4a (r = 0.347, P < 0.05), colec12 (r = 0.463, P < 0.05), CFB (r = 0.446, P < 0.05) and CFHR2 (r = 0.371, P < 0.05), and negatively correlated with the abundances of urinary complement SERPINA5 (r = -0.294, P < 0.05). This evidence concerns the gene SERPINA5 and glomerulosclerosis.