cBioPortal analysis in 26 cancer types revealed that SOX9 mutations are highest in COAD with 11.78%, including mutations at 10.77% in 64 cases, amplification at 0.67% in four cases, and deep deletion at 0.34% in two cases, and lowest in THCA (thyroid carcinoma) with 0.2% (amplification of 0.2% in one case) (Figure 4A). The gene discussed is SOX9; the disease is cancer.