SOX9 and cancer: Additionally, our studies indicated that the expression of SOX9 was negatively correlated with multiple immunosuppressants, and many cancer species related to the expression of SOX9 were highly malignant, such as COAD, LAML, ESCA, etc., implying that the correlation between SOX9 expression and immune cell infiltration in pan-cancer may be related to the malignancy of the tumor.