However, although some studies have shown that PADI1 is a poor prognostic factor of artificial cancer in pancreatic cancer and clear renal cell carcinoma and that PADI1 can also participate in the progression of laryngeal squamous cell carcinoma (LSCC), its specific mechanism of action still needs further study (145–147). This evidence concerns the gene PADI1 and familial pancreatic carcinoma.