PADI2 can regulate gene expression, energy metabolism, inflammatory response and signal transduction (MEK1/ERK1/2/IGF2BP1/SOX2, JAK2/STAT3, Wnt/β-Catenin, EGF, Dll4/Notch1) to mediate the proliferation, migration, invasion and drug resistance of tumor cells, thus acting as an oncogene and tumor suppressor gene. The gene discussed is NOTCH1; the disease is neoplasm.