TG and hyperthyroidism: In an efficient manner, hesperidin markedly succeeded in restoring the histological and immunohistochemical disturbances that accompanied the hyperthyroidism status; this was achieved by the renormalization of the histological architecture and the downregulation of the reactivity towards Calcitonin antibody close to the normal group; this improvement occurred probably by anti-inflammatory and anti-oxidative properties that preventing oxidative stress, and by ameliorating thyroid hormones.