As TLR7 dosage has been shown to be increased in individuals with two X chromosomes due to escape from X chromosome inactivation and has also been shown to have increased localization to late endosomes/lysosomes in some SLE patients (59), further examination of whether EGA-treatment can inhibit TLR7 responses is warranted. This evidence concerns the gene TLR7 and systemic lupus erythematosus.