CD8A and metabolic dysfunction-associated steatohepatitis: A recent sutdy reported that hepatic CXCR6+ CD8 T cells are abundant in NASH mice and patients, and IL-5-induced downregulation of FOXO1 and upregulation of CXCR6 trigger hepatic CXCR6+ CD8 T cells to engage in self-attack, thereby harming the liver (117).