Invariant natural killer T (iNKT) cells are elevated in both NASH mouse models and NASH patients, where they secrete a variety of pro-inflammatory cytokines and boost OPN to exacerbate steatosis, NASH, and liver fibrosis, all of which contribute to the progression of MAFLD (96). The gene discussed is SPP1; the disease is metabolic dysfunction-associated steatohepatitis.