However, the effects of IFN-γ treatment were not only confined to tumor cells; priming HER2-CAR T-cells were also shown to upregulate the expression of survivin, an anti-apoptotic protein linked to the pathogenesis of multiple malignancies and autoimmune diseases (265, 266), which improved their persistence and anti-tumor cytotoxicity (264). The gene discussed is BIRC5; the disease is neoplasm.