In this respect, studies have outlined that tumor cells impair the expression of vasculature-related factors, including overexpression of tumor surface endothelin B receptors in thyroid cancer, which leads to intercellular adhesion molecule-1 (ICAM-1) downregulation and, as a consequence, failure of ICAM-1-redirected CAR T-cells to target advanced thyroid cancer (119). This evidence concerns the gene ICAM1 and thyroid cancer.