At first, we would like to acknowledge that there is no consensus in the literature on how to best study neuroinflammation in Huntington’s disease in vivo.36 Despite the methodological differences with first-generation TSPO-specific binding studies, and 11C-PBR28 PEC-CT protocols for healthy volunteers and other disorders, our baseline PET results support a significant value of 11C-PBR28 PECT-CT for in vivo imaging of TSPO and for differentiating Huntington’s disease patients from healthy volunteers. Here, TSPO is linked to Huntington disease.