SFXN1 and breast cancer: As shown in Figure 1g, upregulated mRNA expression levels of SFXN1 were significantly related to poor prognosis in BC patients (HR = 1.39, P = 0.00054) but increased SFXN2 expression was significantly associated with good prognosis in patients with BC (HR = 0.55, P = 1.3 × 10−5).