The results in the current research confirmed the promotive effects of AL137789.1 overexpression on the proliferation, migration, and invasion and its inhibitory effect on the cell cycle of PCa cells (BxPC3 and PANC1), along with reduced expression of E-cadherin and increased expressions of N-cadherin and Vimentin, which enriched the role of AL137789.1 in PCa. Here, CDH2 is linked to posterior cortical atrophy.