Among the medication categories tested, by using medication-related SNPs, IVW initially screened out 10 medication categories (HMG CoA reductase inhibitors, antihypertensives, diuretics, drugs for peptic ulcer and GORD, antithrombotic agents, calcium channel blockers, agents acting on the renin-angiotensin system, drugs used in diabetes, beta blocking agents, and salicylic acid and its derivatives) significantly associated with stroke (Supplementary Tables S2, S3 and Figure 2A), implying a high-risk function on stroke. Here, REN is linked to stroke disorder.