For LAS, nine categories (calcium channel blockers, HMG CoA reductase inhibitors, agents acting on the renin-angiotensin system, antithrombotic agents, diuretics, beta blocking agents, salicylic acid and its derivatives, drugs used in diabetes, and vasodilators used in cardiac diseases) were associated with the advance of LAS in the IVW analysis (Supplementary Tables S14, S15 and Figure 3B). This evidence concerns the gene HMGCR and diabetes mellitus.