For IS, IVW yielded the estimates of the effect of nine medication categories (HMG CoA reductase inhibitors, antihypertensives, diuretics, drugs for peptic ulcer and GORD, antithrombotic agents, calcium channel blockers, agents acting on the renin-angiotensin system, drugs used in diabetes, and beta blocking agents) on IS (Supplementary Tables S6, S7 and Figure 2B), as shown in the figure. Here, REN is linked to diabetes mellitus.