For example, 10 medication categories (HMG CoA reductase inhibitors, antihypertensives, diuretics, drugs for peptic ulcer and GORD, antithrombotic agents, calcium channel blockers, agents acting on the renin-angiotensin system, drugs used in diabetes, beta blocking agents, and salicylic acid and its derivatives) significantly associated with stroke. The gene discussed is REN; the disease is peptic ulcer disease.