BRCA1 and cancer: Panou et al., in their targeted capture and next generation sequencing study of 85 cancer susceptibility genes on germline DNA from 198 malignant mesothelioma patients, found BRCA1 germline mutations in 0.0051 proportion of mesothelioma patients included in their study compared to 0.002 estimate in the non-cancer population (p>0.05).