BRCA2 and pleural mesothelioma: Hiltbrunner et al., in a much larger study based out of Europe, found germline alterations in BRCA2 in 2.3% of malignant mesothelioma cases, with a slightly higher prevalence in pleural mesotheliomas (2.5%) as compared to peritoneal mesotheliomas (1.7%) [33].