Also, Wang et al. found that the level of RA and the expression level of Zonula occludens-1 (ZO-1) and occludin in the retinal pigment epithelium (RPE) –choroid complex of lens induced myopia (LIM) guinea pigs were significantly increased, whereas the expression of RA and the proteins of ZO-1and occludin in LIM guinea pigs treated with RA antagonists were inhibited (Wang et al., 2014). The gene discussed is OCLN; the disease is myopia.