Considering an important role of MIF in NLRP3 activation in human peripheral blood monocytes, MIF inhibition may prevent stress-induced monocyte migration and consequent neuroinflammation or may be considered as a potential strategy to suppress tumor growth and overcome therapeutic resistance in some cancer patients (Samadi et al., 2015; de Azevedo et al., 2020). The gene discussed is MIF; the disease is cancer.