However, Colombo et al. (2019) have recently evaluated basal and stimulated adrenal function in 12 thyroid cancer patients receiving tyrosine kinase inhibitors and demonstrated a progressive ACTH increase with normal plasma cortisol levels in 10 patients, whereas the diagnosis of primary adrenal insufficiency was confirmed in 6 out of 10 patients after the detection of a blunted plasma cortisol response upon ACTH stimulation. This evidence concerns the gene POMC and thyroid cancer.