TREH and COVID-19: The gene with the strongest association was TREH, encoding the trehalase enzyme, which hydrolyses trehalose, with rare (gnomAD allele frequency [AF] < 10−4) nonsynonymous variants associated with a lower risk of life-threatening COVID-19 (OR = 0.12[95% CI 0.05–0.28], P = 1.9 × 10−6; Additional file 2: Table S3).