TLR3 and influenza: Through a candidate approach focusing on influenza susceptibility genes, the COVID Human Genetics Effort (CHGE [14]) provided proof-of-concept that autosomal inborn errors of TLR3-dependent and -independent type I interferon (IFN) immunity, including autosomal recessive (AR) deficiencies of IFNAR1 or IRF7, can underlie critical COVID-19 [15].