In analyses of genes with rare variants increasing the risk of life-threatening COVID-19, TLR7 was, by two orders of magnitude, the most significant gene, with 51 carriers (1.6%) of at least one rare (gnomAD AF < 0.01) missense or pLOF variant in patients versus two carriers (0.1%) in controls (OR = 8.41[95% CI 1.9–35.5], P = 8.95 × 10−5) (Table 3). The gene discussed is TLR7; the disease is COVID-19.