In analyses of genes for which rare predicted loss-of-function (pLOF) variants were associated with an increase in the risk of life-threatening COVID-19 (Table 2), the strongest association was that for NPC2, for rare (gnomAD AF < 0.01) pLOF variants, with 28 heterozygous carriers among patients (0.9%), and four heterozygous carriers (0.3%) among controls (OR = 5.41 [95% CI 1.8–16.4], P = 5.8 × 10−4). This evidence concerns the gene NPC2 and COVID-19.