IFNG and neoplasm: By Irradiating the mice engrafted with the B16 melanoma cells for 15 Gy × 1 fraction or 5 Gy × 3 fractions, Lugade et al. [95] proved that the single-fractioned radiation increased the antigen availability and the number of tumor-specific T-cells secreting IFN-γ in the tumor-draining lymph node to a more considerable extent than the multi-fractionated RT did.