PARP1 and osteosarcoma: Consistent with the drug responses in the GDSC2 dataset, we observed that Ewing’s sarcoma cell lines demonstrated the greatest sensitivity to PARP inhibition (average IC50 = 0.12 μM), and rhabdomyosarcoma and osteosarcoma cell lines were the least sensitive overall (average IC50 = 3.03 μM and 3.74 μM, respectively; Fig. 1e).