According to a study on cardiac I/R, iNOS/NO-mediated factors, such as the formation of oxy-radicals like peroxynitrites, have cytotoxic effects on nearby cardiomyocytes due to the start of lipid peroxidation, inhibition of mitochondrial respiratory chain enzymes, and release of iron from ferritin, and also contribute to cardiac dysfunction after infarction [36, 70]. The gene discussed is INSR; the disease is infarction.