Low expression of BHLHE40, LDLR and EMP1 is associated with good prognosis in several cancers, such as pancreatic, urothelial, renal and ovarian cancers [38], while an overexpression of LDLR (Low Density Lipoprotein Receptor) and BHLHE40 (Basic Loop Helix family member e40) is described in colorectal cancer and correlates with poor overall survival [34, 39]. This evidence concerns the gene BHLHE40 and cancer.