ERRFI1 and colorectal carcinoma: In line with this two-tiered model in which ERRFI1 regulates EGFR, ERRFI1 genetic silencing increased both phosphorylated and total EGFR abundance as well as EGFR-mediated wild-type RAS reactivation in KRASG12D-mutant CRC cells (Fig. 3H and Fig. 4B).