AKT1 and colorectal carcinoma: Various genomic alterations mediate the initiation, progression, and metastasis of CRC, including APC, TP53, SMAD4, and CTNNB1, as well as oncogenic mitogenic signaling such as selected receptor tyrosine kinases, phosphatidylinositol 3-kinase/AKT or RAS/RAF signaling [5–7].