Gong et al.12 revealed that the SNPs in P2RX7 were related to IL-1β secretion, and considered that these SNPs, such as Ala348 to Thr (rs1718119), His155 to Tyr (rs208294), Glu496 to Ala (rs3751143), Arg307 to Gln (rs28360457) and Thr357 to Ser (rs2230911), were related to the pathogenesis of gout. Here, P2RX7 is linked to gout.