EGFR and lung cancer: An analysis of 3-year and 20-year PM2.5 cumulative exposure (Methods) revealed that the frequency of EGFR-driven lung cancer cases was significantly higher after 3 years of high air pollutant exposure compared with low exposure (EGFR mutation frequency in high compared with low pollution (Methods): 73% versus 40%, respectively, P = 0.03; Extended Data Fig. 1d,e).